Publications

Publications, Journals, Magazines

  • Hofmann KP, Pulvermuller A, Buczylko J, VAN HOOSER JP, and Palczewski K: The role of arrestin in regeneration pathway of rhodopsin. J Biol Chem 1992;267:15701-15706.
  • Palczewski K, Buczylko J, VAN HOOSER JP, Carr S, Huddleston MJ, and Crabb JW: Identification of the autophosphorylation sites in rhodopsin kinase. J Biol Chem 1992;267:18991-18998.
  • Gorczyca W, VAN HOOSER JP, and Palczewski K: Nucleotide inhibitors and activators of retinal guanylate cyclase. Biochemistry 1994;33:3217-3222.
  • Ohguro H, VAN HOOSER JP, Milam AH, and Palczewski K: Rhodopsin phosphorylation and dephosphorylation in vivo. J Biol Chem 1995;270:14259-14262.
  • Semple-Rowland SL, Lee NR, VAN HOOSER JP, Palczewski K, and Baehr W: A null mutation in the photoreceptor guanylate causes the retinal degeneration chicken phenotype. Proc Natl Acad Sci USA 1998;95:1271-1276.
  • Saari JC, Garwin GG, VAN HOOSER JP, and Palczewski K: Reduction of all-trans-retinal limits regeneration of visual pigment in mice. Vision Research 1998;38:1325-1333.
  • Otto-Bruc AE, Fariss RN, VAN HOOSER JP, and Palczewski K: Phosphorylation of photolyzed rhodopsin is calcium-insensitive in retina permeabilized by ?-toxin. Proc Natl Acad Sci USA 1998;95:15014-15019.
  • Palczewski K, VAN HOOSER JP, Garwin GG, Chen J, Liou GI, and Saari JC: Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry 1999;38:12012-12019.
  • Palczewski K, VAN HOOSER JP, and Ohguro H: Identification of residues that are phosphorylated within a receptor, In: JL Benovic (ed.): Regulation of G Protein-coupled Receptor Function and Expression. c 1999 Wiley-Liss, New York; Chapter 4: pp. 69-91.
  • Otto-Bruc AE, VAN HOOSER JP, and Fariss RN: Use of ?-toxin permeabilized photoreceptors in in vitro phototransduction studies. Meth Enzymol 2000;316B:269-278.
  • VAN HOOSER JP, Garwin GG, and Saari JC: Analysis of the visual cycle in transgenic mice. Meth Enzymol 2000;316B:565-575.
  • Driessen CA, Winkens HJ, Hofmann K, Kuhlmann LD, Janssen BPM, VanVugt AHM, VAN HOOSER JP, Wieringa B, Deutman AF, Palczewski K, Ruether K, and Janssen JJM: Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters. Molec Cell Biol 2000;20:4275-4287.
  • VAN HOOSER JP, Aleman TS, He YG, Cideciyan AV, Kuksa V, Pittler TSJ, Stone EM, Jacobson SG, and Palczewski K: Restoration of visual pigment and function in the RPE65 mull mutant murine model of Leber's congenital amaurosis with oral 9-cis-retinal. Proc Natl Acad Sci USA 2000;97:8623-8628.
  • McBee JK, VAN HOOSER JP, Jang GF, and Palczewski K: Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. J Biol Chem 2001;276(51):48483-48493.
  • Jang GF, VAN HOOSER JP, Kuksa V, McBee JK, He YG, Janssen, JJ, Driessen, CAGG, and Palczewski K: Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. J Biol Chem 2001;276(35):32456-32465.
  • VAN HOOSER JP, Liang Y, Maeda T, Kuksa V, Jang GF, He YG, Rieke F, Fong HK, Detwiler PB, and Palczewski K: Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem 2002;277(21):19173-19182.
  • Kuksa V, Bartl F, Maeda T, Jang GF, Ritter E, Heck M, VAN HOOSER JP, Liang Y, Filipek S, Gelb MH, Hofmann KP, and Palczewski K: Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals. J Biol Chem 2002;277(44):42315-42324.
  • Maeda T, VAN HOOSER JP, Driessen CA, Filipek S, Janssen JJ, Palczewski K. Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo. Neurochem 2003 May;85(4):944-56.
  • VAN HOOSER JP. A Market Yearning for Innovation: Research Turned Entrepreneur Revolutionizes the Lab. WBBA 2007;6-7.
  • VAN HOOSER JP. A Case for Automating the Vivarium. Arizona Branch AALAS Newsletter 2007;20(4):7-8.
  • VAN HOOSER JP. Research Scientist Expertise Brings Safety and Efficiency to the Research Lab. University of Washington Tech Transfer Annual Report FY2007:14.
  • Robson KM, Bachtel A, and VAN HOOSER JP. Designing an innovative and effective pool of assistant instructors. Lab Manager 2008 (in preparation).
  • VAN HOOSER JP. From Concept to Commerce. ALN Magazine 2008;7(1):33-35.
  • VAN HOOSER JP. Automated Workstation for Disinfecting Animal Cages and Methods of Use Thereof. Lab Animal 2008;(submitted).

Selected Abstracts

  • RPE65 Null Mutation: Impact on Morphology and Development of Retinal Pigment Epithelial (RPE) and Photoreceptor Cells. (Y.G. He1 and J.P. VAN HOOSER1) 1Dept. of Ophthalmology, University of Washington, Seattle, WA.
  • Retinoid Composition and Dark Adaptation in 11-cis-Retinol Dehydrogenase Knockout Mice. (C. Driessen1, H. Winkens1, J.P. VAN HOOSER2, A. Deutman1, K. Palczewski2, K. Reuther3, and J. Janssen1) 1University of Nijmegen, Nijmegen, The Netherlands; 2Dept. of Ophthalmology, University of Washington, Seattle, WA; 3Humbolt University, Berlin, Germany.
  • Retinoid Impairment of the Pupillary Light Reflex in Rpe65-/- Mice and Patients with Leber Congenital Amaurosis. (T.S. Aleman1, M. Scott1, R-J. Chen1, J.D. Chico1, A.Y.Cheung1, J.P. VAN HOOSER2, T.M. Redmond3, K. Palczewski2, S.G. Jacobson1, A.V. Cideciyan1) 1Scheie Eye Institute, Dept. of Ophthalmology, University of Pennsylvania, Philadelphia, PA.; 2Dept. of Ophthalmology, University of Washington, Seattle, WA; 3Laboratory of Retinal Cell and Molecular Biology, NEI/NIH, Bethesda, MD.
  • Designing an Innovative and Effective Pool of Assistant Instructors. (K.M. Robson1, A. Bachtel1 and J.P. VAN HOOSER1) 1Animal Use Training Program, University of Washington, Seattle, WA.
  • What Do You Mean I Never Took That Class? Documentation and Record Keeping. (A. Bachtel1, K.M. Robson1, and J.P. VAN HOOSER1) 1Animal Use Training Program, University of Washington, Seattle, WA.

Research and Professional Experience

  • 1991 Visiting Research Scientist, Institut fur Biophysic und Strahlenbiologie, Universitat Freiburg, Freiburg, Germany (Laboratory of Dr. K.P. Hofmann)
  • 1991-1992 Research Technician I, R.S. Dow Neurological Sciences Institute, Good Samaritan Hospital & Medical Center, Portland, Oregon (Laboratory of Dr. Krzysztof Palczewski)
  • 1992 Visiting Research Scientist, Institut fur Biophysic und Strahlenbiologie, Universitat Freiburg, Freiburg, Germany (Laboratory of Dr. K.P. Hofmann)
  • 1992-2002 Research Scientist, Department of Ophthalmology, University of Washington, Seattle, Washington (Laboratory of Dr. Krzysztof Palczewski)
  • 1992-present Founder & Principal, SPCI Retina, Inc., d/b/a InVision BioResources, Seattle, Washington
  • 2000-2003 Research Scientist, Novasite Pharmaceuticals, Inc., San Diego, California
  • 2002-present Research Coordinator, Office of Animal Welfare, University of Washington, Seattle, Washington
  • 2002-present Manager, Animal Use Training Program, Department of Comparative Medicine, University of Washington, Seattle, Washington
  • 2006-present Founder, President & Chief Scientific Officer, Acedia, Inc., d/b/a Cirrus BioSystems, Seattle, Washington
  • 2007-present Senior Compliance Analyst, Office of Animal Welfare, University of Washington, Seattle, Washington